Thirty patients are currently in critical condition at the various COVID-19 treatment centres in the country.
The number of cases has also risen to 17, 351 with some 12, 994 recovered patients.
President Akufo-Addo announced the latest figures in his 13th COVID-19 update address to the nation on Sunday.
“30 persons are severely and critically ill, and we have 112 sad deaths, constituting 0.6% of positives, as we maintain one of the lowest death rates in the world.
“We have 4, 245 active cases, having conducted 294, 876 tests, one of the highest on the continent,” the President said.
According to President Akufo-Addo, one of the key objectives of the COVID-19 fight is to save lives and reduce the number of deaths.
He also expressed worry about a Ghana Health Service report, which suggests that most of the patients, who had died from the disease, passed on either on arrival at the hospital or within 48 hours after their arrival.
As it stands now, all 16 regions in Ghana have confirmed cases of COVID-19 after the country recorded its first case on March 12.